Inorganic Chemistry: A Textbook

Working from basic chemical principles, Metals in Medicine 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: • Metallo-Drugs and their action • Platinum drugs for treating cancer • Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium • Responsive Metal Complexes • Treating arthritis and diabetes with metal complexes • Metal complexes for killing bacteria, parasites and viruses • Metal ion imbalance and its links to diseases including Alzheimer's, Wilson's and Menkes disease • Metal complexes for detecting disease • Nanotechnology in medicine Now in full colour, Metals in Medicine 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.

“The Organometallic Chemistry of N-heterocyclic Carbenes” describes various aspects of N-heterocyclic Carbenes (NHCs) and their transition metal complexes at an entry level suitable for advanced undergraduate students and above. The book starts with a historical overview on the quest for carbenes and their complexes. Subsequently, unique properties, reactivities and nomenclature of the four classical NHCs derived from imidazoline, imidazole, benzimidazole and 1,2,4-triazole are elaborated. General and historically relevant synthetic aspects for NHCs, their precursors and complexes are then explained. The book continues with coverage on the preparation and characteristics of selected NHC complexes containing the most common metals in this area, i.e., Ni, Pd, Pt, Ag, Cu, Au, Ru, Rh and Ir. The book concludes with an overview and outlook on the development of various non-classical NHCs beyond the four classical types. Topics covered include: • Stabilization, dimerization and decomposition of NHCs • Stereoelectronic properties of NHCs and their evaluation • Diversity of NHCs • Isomers of NHC complexes and their identification • NMR spectroscopic signatures of NHC complexes • normal, abnormal and mesoionic NHCs “The Organometallic Chemistry of N-heterocyclic Carbenes” is an essential resource for all students and researchers interested in this increasingly important and popular field of research.