Monsuno hurtled through space eons before man existed. Upon burning through the planet's atmosphere and crashing to Earth, it brought chaos and the extinction of the dinosaurs. Then, it vanished. Now, Monsuno is back. Is the Earth doomed?
Chase Suno and friends Bren and Jinja learn that Jeredy, Chase's father and a scientist who worked for S.T.O.R.M., is missing. At the lab, they find what Jeredy left behind for his son. Chase then proceeds to learn how to use his Monsuno.
Chase leads a brave exfiltration unit into the S.T.O.R.M. facility to save Quickforce, an unpredictable Monsuno that his father had created, after learning that Quickforce is being held captive, and is being experimented on, by S.T.O.R.M.
Our three heroes venture into the big city of Axistown to search for a lead on Jeredy. Soon they meet a wealthy old woman who sends them into the Underground on Jeredy's trail, but the Underground turns out to be a Fight Club for Monsuno.
When Chase receives a garbled message from his father asking him to meet, our hero cannot resist. Chase then heads out alone to the meeting's location, an abandoned facility, only to find Darkspin and Medea waiting for him instead.
Desperately in need of key information to help them on their quest, our heroes travel to Mandala, to the Ancient Library of Tebab, where they become captured by the evil Bookman, and encounter a young controller named Beyal.
S.T.O.R.M. sets up a blockade to attempt to prevent our heroes from leaving Mandala. Chase becomes convinced that the only way he and his compadres have a chance of surviving this game of cat and mouse is by attacking S.T.O.R.M.
Chase, Jinja, Bren, and Beyal head into the Lowlands to lay low, where they meet Dax. After losing a battle to Chase, Dax vows revenge. Beyal experiences unexplainably frightening visions. Dr. Klipse invites Chase to join his organization.
While following Dax, the Core-Tech team happens to catch sight of Jeredy Suno, when they are suddenly attacked by Dark Spin mercenaries. Before being separated from his son once again, Jeredy gives Chase a new Monsuno named Evo.
Dax joins the team, but nobody is pleased about this. Chase suspects that Dax is withholding information about his father. Dax denies knowing anything of substance but discloses that he heard an old man say something about Coastal City.
After Beyal convinces Chase that Dax should be the fifth member of the group, things take a turn for the worse when Dax sells them out, even helping Charlemagne capture them. However, things are not always what they seem.