In this romantic adventure-comedy set in one of the world's most mysterious, chaotic and often dangerous cities, a sharp-witted, very honorable American fortune hunter (Penn) and a beautiful, fairly honorable missionary (Madonna) reluctantly join forces to seek out a legendary cache of stolen opium. Together, these unlikely companions confront a variety of every unsavory thug and gangster imaginable all of whom want the opium all for themselves...and haven't a grain of honor between them.
