Sherlock Holmes in the 22nd Century - Season 1

When New London is caught in the grip of a massive crime wave, Holmes uses his eyes and intellect to deduce that the heat of the criminal activity lies in the city's long abandoned underground. With the guidance of the street-wise Baker Street Irregulars, Holmes, Watson and Lestrade plunge into the shadowy depths to foil the plot, but lose Watson when their wild escape ends with a train crash into the Thames. Only then does Holmes realize that the robot is becoming a true friend.

On the moon, in the domed Galileo City, an old legend appears to be true when three children go missing and eerie howling can be heard echoing throughout the resort. But Sherlock Holmes suspects there is an all too human reason behind this supernatural phenomenon. His sleuthing quickly dispatches the mythical beast for what it is: trickery created by Moriarty to vacate the moon of its tourists so that its powerful defense and life support systems would be his from which to rule the earth. Though Moriarty escapes, Holmes and Lestrade cleverly foil the evil plot and save the day, the moon, and the earth!

When Lestrade corners the notorious Fenwick and his crew in an abandoned building, all she finds are innocent, mild-mannered citizens. Confounded, she calls in Sherlock Holmes to investigate. He quickly deduces that the citizens are indeed the culprits… and that Moriarty has forced a renowned plastic surgeon to use his DNA Washer device to completely alter their appearances! Using the device on himself, a disguised Holmes foils Moriarty's evil plot to switch the leaders of the free world with his own look-alike henchmen!

Someone has robbed the supposedly impenetrable safe room at Genie Tech. In the locked room – with no window or other way out - Sherlock Holmes discovers tiny scales which prove to belong to a mysterious unknown species of snake. Is this the work of the eminent herpetologist Grimsby Roylott who is trying desperately to keep the old London Zoo afloat? Or, as Watson suspects, is it the work of Forest Chapman, the proprietor of the spooky Mythological Museum where monstrous hybrid creatures are created and displayed to the delight of 22nd Century kids? Holmes looks past the obvious to discover that someone has mixed his own DNA with that of a python in order to commit the daring robberies. Holmes must then wrestle with the snake-man for his very life to win the day!

In seclusion at his remote country estate, radical anti-tech group leader Joseph Openshaw blacks out after opening a mysterious envelope containing only a cryptic note and five orange seeds. Sherlock Holmes soon discovers that the pips are poisoned and that Joseph was targeted because he – along with his brother Elias – had invented a cyber nest that could wipe out all the computers they despise forever. Though the two brothers stopped before unleashing it, Holmes now finds that Moriarty wants to use the invention to destroy New Scotland Yard's databanks and hold the world hostage. In order to get the antidote for the poison, Holmes gives Moriarty the cyber nest… but not before knowing that it is useless. All are saved and Watson helps Joseph's young son, John, learn that the true value of someone is what's in their heart.

Alexander Holder catches his own son Arthur stealing the top secret computer chip that the famous Payne computer dynasty family had entrusted him to safeguard. Why would Holder's son betray him? Did Holder's son betray him? In order to save the situation, Holmes must sift through the motives, secrets and misunderstandings of two families: not only those of Arthur, but those of the 10-year-old genius son, Helfand Payne III, and his father, Helfand Payne II, and Arthur's sister Mary and her cad of a boyfriend. Sherlock recovers the stolen chip and sorts everything out. All is made right and both families realize they have a lot more communicating to do!

The blinding flashes of disintegration haunt Watson after he witnesses Holmes and Moriarty fall from their rooftop battle into New London's laser wave sanitation grid. Despite his devastation at losing his friend, crime doesn't stop and Lestrade brings Watson to the room of a young hotshot laser tag tournament star who has been frozen solid by a freeze ray. Why? Was it because the hotshot was cheating? Or, did an opponent merely want to take him out of the competition? While investigating, Watson discovers that Holmes is still alive and in disguise! Having discovered that the marksman who froze the laser tag star was the same person who was paid by Moriarty to interfere in the rooftop battle; Holmes observes unobserved. In a gripping showdown in the laser tag arena, Holmes confronts and unmasks the culprit. Unfortunately, Holmes is not the only clever one – Moriarty is still alive, too, and still out there…somewhere.

After a break in at 10 Downing Street, it appears that the thief was only able to steal one of the African dolls from the Prime Minister's collection, and was not able to find the secret safe where Lord Devlin had hidden the top secret security plans. While Lestrade helps Greyson - who must interrupt his meeting with the famous recluse millionaire Lord Bork – to retrieve the precious doll, Holmes and Watson conduct their own investigation. After all, Holmes believes that the safe was found, that the doll is just a decoy, and that Devlin himself is somehow involved. Holmes sets a trap to catch Devlin, discovering that Moriarty has been masquerading as Lord Bork! Though Moriarty gets away, the plans are recovered before and the doll is returned safely.

At the insistence of a memo from Lestrade, the Prime Minister contacts Sherlock Holmes when the top secret virtual reality chip, called the Mazarin Chip, is stolen. But the memo is a forgery: a trap to get the Prime Minister and Holmes to Baker Street where Moriarty then descends upon them, trapping Holmes in a virtual prison and kidnapping the Prime Minister. Holmes must escape his virtual prison and discover where Moriarty really is before he is able to create 10 Downing Street with the Mazarin Chip and access all the Prime Minister's power. Holmes is able to free himself then the Prime Minister, but must use Moriarty's own methods against him to retrieve the chip. Holmes saves the day…but Moriarty gets away.