ASM Books
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Gram-Positive Pathogens
by Various Authors
Part 29 of the ASM Books series
Gram-positive bacteria, lacking an outer membrane and related secretory systems and having a thick peptidoglycan, have developed novel approaches to pathogenesis by acquiring (among others) a unique family of surface proteins, toxins, enzymes, and prophages. For the new edition, the editors have enhanced this fully researched compendium of Gram-positive bacterial pathogens by including new data generated using genomic sequencing as well as the latest knowledge on Gram-positive structure and mechanisms of antibiotic resistance and theories on the mechanisms of Gram-positive bacterial pathogenicity. This edition emphasizes streptococci, staphylococci, listeria, and spore-forming pathogens, with chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically, in an attempt to understand the strategies used by these bacteria to cause human disease.
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Antibiotics
Challenges, Mechanisms, Opportunities
by Christopher Walsh
Part 30 of the ASM Books series
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.
This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.
Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:
• What are antibiotics?
• Where do antibiotics come from?
• How do antibiotics work?
• Why do antibiotics stop working?
• How should our limited inventory of effective antibiotics be addressed?
Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
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Biological Safety
Principles and Practices
by Various Authors
Part 31 of the ASM Books series
Biological safety and biosecurity protocols are essential to the reputation and responsibility of every scientific institution, whether research, academic, or production. Every risk-no matter how small-must be considered, assessed, and properly mitigated. If the science isn't safe, it isn't good. Now in its fifth edition, “Biological Safety: Principles and Practices” remains the most comprehensive biosafety reference.
Led by editors Karen Byers and Dawn Wooley, a team of expert contributors have outlined the technical nuts and bolts of biosafety and biosecurity within these pages. This book presents the guiding principles of laboratory safety, including: the identification, assessment, and control of the broad variety of risks encountered in the lab; the production facility; and, the classroom.
Specifically, “Biological Safety” covers
• protection and control elements-from biosafety level cabinets and personal protection systems to strategies and decontamination methods
• administrative concerns in biorisk management, including regulations, guidelines, and compliance
• various aspects of risk assessment covering bacterial pathogens, viral agents, mycotic agents, protozoa and helminths, gene transfer vectors, zooonotic agents, allergens, toxins, and molecular agents as well as decontamination, aerobiology, occupational medicine, and training
A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological safety is also a critical reference for laboratory managers, and those responsible for managing biohazards in a range of settings, including basic and agricultural research, clinical laboratories, the vivarium, field study, insectories, and greenhouses.
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Dark Art of Blood Cultures
by Various Authors
Part 32 of the ASM Books series
In the clinical microbiology laboratory, blood is a critical diagnostic sample that, in the majority of cases is sterile (or is it?). However, when microbes gain access to and multiply in the bloodstream, it can result in life-threatening illnesses including sepsis. Mortality rates from bloodstream infection and sepsis range from 25% to 80%, killing millions of people annually. Blood cultures are a vital technology used in the microbiology laboratory to isolate and identify microbes and predict their response to antimicrobial therapy.
“The Dark Art of Blood Cultures”, edited by Wm. Michael Dunne, Jr., and Carey-Ann D. Burnham, surveys the entire field of blood culture technology, providing valuable information about every phase of the process, from drawing samples to culture methods to processing positive cultures. “The Dark Art of Blood Cultures” is organized around several major topics.
• History of blood culture methods. Details the timeline of blood culture methods from manual through automated and describes the technological development of the leading automated blood culture systems (Bactec, BacT/Alert, and VersaTREK).
• Manual and automated blood culture methods. Critiques manual and automated methods for setting up blood cultures for adult and pediatric patients.
• Detection of pathogens directly from blood specimens. Describes currently available CE marked and FDA-cleared commercial tests using both phenotypic and genotypic markers, including their strengths and limitations.
• The workflow of culturing blood. Includes best practices from specimen collection to culture system verification, processing positive cultures for microbe identification and antibiotic susceptibility determination, along with the epidemiology of positive blood cultures and the value of postmortem blood cultures.
• Microorganisms in the blood. Examines the concept of a blood microbiome in healthy and diseased individuals.
“The Dark Art of Blood Cultures” is a resource that clinicians, laboratorians, lab directors, and hospital administrators will find engaging and extremely useful.
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Manual of Environmental Microbiology
by Various Authors
Part 33 of the ASM Books series
The single most comprehensive resource for environmental microbiology
Environmental microbiology, the study of the roles that microbes play in all planetary environments, is one of the most important areas of scientific research. “The Manual of Environmental Microbiology”, Fourth Edition, provides comprehensive coverage of this critical and growing field.
Thoroughly updated and revised, the Manual is the definitive reference for information on microbes in air, water, and soil and their impact on human health and welfare. Written in accessible, clear prose, the manual covers four broad areas: general methodologies, environmental public health microbiology, microbial ecology, and biodegradation and biotransformation. This wealth of information is divided into 18 sections each containing chapters written by acknowledged topical experts from the international community.
Specifically, this new edition of the Manual
• Contains completely new sections covering microbial risk assessment, quality control, and microbial source tracking
• Incorporates a summary of the latest methodologies used to study microorganisms in various environments
• Synthesizes the latest information on the assessment of microbial presence and microbial activity in natural and artificial environments
“The Manual of Environmental Microbiology” is an essential reference for environmental microbiologists, microbial ecologists, and environmental engineers, as well as those interested in human diseases, water and wastewater treatment, and biotechnology.
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The Fungal Kingdom
by Joseph Heitman
Part 35 of the ASM Books series
Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.
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Tuberculosis and Nontuberculous Mycobacterial Infections
by Various Authors
Part 36 of the ASM Books series
Complete coverage of every aspect of tuberculosis and related mycobacterial infections
"Tuberculosis appears to be as old as humanity itself." Despite many advancements since the 1882 identification of Mycobacterium tuberculosis as the causative agent of tuberculosis, it remains one of the top 10 causes of death worldwide and threatens the effectiveness of our therapeutic arsenal. In 2015, 1.8 million people died of tuberculosis and almost half a million new cases of multidrug-resistant tuberculosis were diagnosed.
For “Tuberculosis and Nontuberculous Mycobacterial Infections”, Dr. Schlossberg assembled an international team of experts to write about nearly every facet of the prevention, diagnosis, and treatment of tuberculosis and nontuberculous mycobacterial infections. In addition to presenting the latest clinical data, epidemiological findings, and policy and strategy recommendations of the World Health Organization, four new chapters cover topics of critical importance:
• The role of therapeutic drug monitoring in mycobacterial infections
• The public health issues of refugees and migrants, and their exposure and transmission of tuberculosis resulting from humanitarian crises
• Diabetes mellitus as a significant risk factor for tuberculosis
• The increased risk of tuberculosis reactivation in people taking tumor necrosis factor alpha inhibitors and other biopharmaceuticals
Other chapters provide detailed information on the clinical, public health, and policy aspects of tracking and treating tuberculosis, including:
• The many presentations of tuberculosis, from pulmonary to ocular and cardiovascular to urogenital
• The complications that tuberculosis and antituberculosis therapy cause to the hematologic and endocrine systems
• Tuberculosis during pregnancy and in infants and children
• Treatment of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis
• Development of new vaccines
• Nontuberculous infections caused by mycobacteria found throughout our environment
The seventh edition of “Tuberculosis and Nontuberculous Mycobacterial Infections” is an essential resource for anyone working to prevent and treat tuberculosis and associated infections, from infectious disease specialists and pulmonologists to scientists, policymakers, and epidemiologists.
A truly modern book that offers students, practitioners, and all readers the chance for a full immersion into the science of tuberculosis.
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Tuberculosis and the Tubercle Bacillus
by Various Authors
Part 37 of the ASM Books series
Can today's innovative practices and molecular tools tame this ancient disease?
One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035.
This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs.
• Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB.
• Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis.
• Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF.
• Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated.
The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.
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Women in Microbiology
by Various Authors
Part 38 of the ASM Books series
Many girls want to become scientists when they grow up, just like many boys do. But for these girls, the struggle to do what they love and to be treated with respect has been much harder because of the discrimination and bias in our society. In Women in Microbiology, we meet women who, despite these obstacles and against tough odds, have become scientific leaders and revered mentors. The women profiled in this collection range from historic figures like Alice Catherine Evans and Ruth Ella Moore to modern heroes like Michele Swanson and Katrina Forest.
What binds all of these remarkable women are a passion for their work, a zest for life, a warm devotion to mentoring others-especially younger women-and a sense of justice and fairness that they are willing to fight tirelessly to obtain. Each story is unique, but each woman featured in Women in Microbiology has done so much to expand our knowledge of the natural world while also making it easier for the next generation of scientists to work collaboratively and in an atmosphere where people are judged by their intellect, imagination, skill, and commitment to service regardless of gender or race.
“Women in Microbiology” is a wonderful collection of stories that will inspire everyone, but especially young women and men who are wondering how to find their way in the working world. Some of the names are familiar and some are lesser known, but all of the stories arouse a sense of excitement, driven by tales of new, important scientific insights, stories of overcoming adversity and breaking boundaries, and the inclusion of personal tips and advice from successful careers. These stories are proof that a person can live a balanced and passionate life in science that is rich and rewarding.
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Zoonoses
Infectious Diseases Transmissible from Animals to Humans
by Various Authors
Part 39 of the ASM Books series
Zoonoses are a persistent threat to the global human health. Today, more than 200 diseases occurring in humans and animals are known to be mutually transmitted. Classical infectious diseases, such as rabies, plague, and yellow fever, have not been eradicated despite major efforts.
New zoonotic diseases are on the increase due to global conditions such as overpopulation, wars, and food scarcity, which facilitate human contact with rodents, stray animals, and their parasites. In addition, humans are unwittingly becoming accidental hosts and new links in an infectious chain by engaging in activities such as survival training, which involves camping in open areas and consumption of raw or insufficiently cooked food. Zoonotic infections cause a variety of symptoms that often do not provide clear evidence of a known disease. “Zoonoses”, Fourth Edition, describes most occurring worldwide zoonosis and facilitates the identification, diagnosis and treatment of zoonotic infections. Written by a team of doctors, medical microbiologists and veterinarians, this completely, revised edition covers all aspects of the epidemiology and prevention of zoonotic diseases through clear descriptions of various illnesses. Specifically, this fourth edition covers zoonosis caused by
• viruses, bacteria, fungi and parasites
• infections caused by animal bites
• infections and intoxications by animal foods
• Iatrogenic transmission of zoonotic pathogens
Zoonoses is an indispensable reference for clinicians and laboratorians.
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Molecular Genetics of Mycobacteria
by Various Authors
Part 42 of the ASM Books series
A comprehensive collection of perspectives by experts in mycobacterial molecular biology
Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today.
Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge.
Written by leading experts in the field, “Molecular Genetics of Mycobacteria”, Second Edition,
• Discusses key areas of current research in mycobacterial genetics
• Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis
• Presents genetic approaches for manipulating M. tuberculosis
This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.
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Antibodies for Infectious Diseases
by Various Authors
Part 44 of the ASM Books series
State-of-the-art reviews covering major aspects of antibodies and intervention against infectious diseases.
The connection between antibodies and infectious diseases has spawned entire related fields of study. Antibodies for Infectious Diseases presents perspectives from leading research scientists and summarizes the amazing progress in this area into a single definitive source.
Providing a broad survey of the most important aspects of the field of antibodies for infectious diseases, this book
• presents general features pertaining to structure, function, isotype, and the role of complement in antibody function
• examines the role of antibodies in antimicrobial immunity with specific targets
• details new methods for expression of monoclonal antibodies, in plants or by transfer of antibody genes for in vivo expression in treated subjects
“Antibodies for Infectious Diseases” is a comprehensive reference for researchers, pharmaceutical developers, and health care professionals on the status of the development of antibody-based therapies for treating infectious diseases. It is also useful as supplemental reading for upper-level life sciences students.
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Mobile DNA III
by Various Authors
Part 45 of the ASM Books series
An exploration of the raw power of genetic material to refashion itself to any purpose...
Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome. Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability.
Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that
• covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsible
• presents a detailed account of the many different recombination systems that can rearrange genomes
• examines the tremendous impact of mobile DNA in virtually all organisms
“Mobile DNA III” is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms.
Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.
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Plasmids
Biology and Impact in Biotechnology and Discovery
by Various Authors
Part 46 of the ASM Books series
Explore the remarkable discoveries in the rapidly expanding field of plasmid biology.
Plasmids are integral to biological research as models for innumerable mechanisms of living cells, as tools for creating the most diverse therapies, and as crucial helpers for understanding the dissemination of microbial populations. Their role in virulence and antibiotic resistance, together with the generalization of "omics" disciplines, has recently ignited a new wave of interest in plasmids.
This comprehensive book contains a series of expertly written chapters focused on plasmid biology, mechanistic details of plasmid function, and the increased utilization of plasmids in biotechnology and pharmacology that has occurred in the past decade.
“Plasmids: Biology and Impact in Biotechnology and Discovery” serves as an invaluable reference for researchers in the wide range of fields and disciplines that utilize plasmids and can also be used as a textbook for upper-level undergraduate and graduate courses in biotechnology and molecular biology.
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Metabolism and Bacterial Pathogenesis
by Various Authors
Part 47 of the ASM Books series
Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesis.
For too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific metabolic pathways used during infection can regulate virulence factor expression and might lead to effective breakthroughs in a variety of treatments.
Editors Paul Cohen and Tyrrell Conway, who pioneered the use of metabolic mutants in competitive colonization assays, an approach now widely used to investigate the nutrition of pathogens in vivo, are uniquely qualified to advance our knowledge of this integrative field of research. They convened a group of contributors who are breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis to share their expert perspectives and outlook for the future.
Beginning with overviews, “Metabolism and Bacterial Pathogenesis” covers
• a wide range of diseases and both Gram-positive and-negative bacteria that serve as model systems for in vitro and in vivo investigations
• intracellular, respiratory, and enteric pathogens
• pathogen-specific nutrient acquisition in hosts
• mechanisms of host-driven metabolic adaptation by pathogens
• metabolic regulation of virulence gene expression
Useful for specialists in bacterial pathogenesis and specialists in metabolism as well as molecular biologists, physicians, veterinarians, dentists, graduate and undergraduate students, and laboratory technicians, “Metabolism and Bacterial Pathogenesis” is also essential reading for scientists studying the microbiome.
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Microbial Biofilms
by Various Authors
Part 48 of the ASM Books series
An examination of the research and translational application to prevent and treat biofilm-associated diseases.
In the decade since the first edition of “Microbial Biofilms” was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense.
Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically,
“Microbial Biofilms” provides
• state-of-the-art research in the field of bacterial and fungal biofilms
• detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms
• future areas of research and their translational and clinical applications
Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.
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Diagnostic Medical Parasitology
by Lynne Shore Garcia
Part 49 of the ASM Books series
“Diagnostic Medical Parasitology” covers all aspects of human medical parasitology and provides detailed, comprehensive, relevant diagnostic methods in one volume. The new edition incorporates newly recognized parasites, discusses new and improved diagnostic methods, and covers relevant regulatory requirements and has expanded sections detailing artifact material and histological diagnosis, supplemented with color images throughout the text.
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Infections of Leisure
by Various Authors
Part 50 of the ASM Books series
A day at the beach: delightful, restorative—and potentially dangerous.
Leisure activities, from the mundane to the exotic, expose us to a growing list of pathogenic microbes, some new and many increasingly resistant to current therapies. Common pets, livestock, traveling, and cuisine all have the potential to cause illnesses that may be difficult to diagnose and treat.
Engagingly written by a team of infectious disease specialists and edited by David Schlossberg, Infections of Leisure features 19 chapters focused on the infection risks associated with particular types of activities, including camping, playing sports, interacting with animals, receiving body modifications, and mountain climbing. This new edition includes vibrant, full-color images, recommended readings chosen by expert authors, and practical tips in each chapter.
Useful for health care professionals, microbiologists, and infectious diseases specialists, the information in Infections of Leisure will support confident identification of leisure-associated infections and enable informed choices, as well as provide an understanding of the risks posed to human health by hobbies, exotic foods and travel.
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Molecular Microbiology
Diagnostic Principles and Practice
by Various Authors
Part 51 of the ASM Books series
Presenting the latest molecular diagnostic techniques in one comprehensive volume
The molecular diagnostics landscape has changed dramatically since the last edition of “Molecular Microbiology: Diagnostic Principles and Practice” in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field.
Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors.
“Molecular Microbiology: Diagnostic Principles and Practice”
• Presents the latest basic scientific theory underlying molecular diagnostics
• Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing
• Illustrates and summarizes key concepts and techniques with detailed figures and tables
• Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance
• Advises on the latest quality control and quality assurance measures
• Explores the increasing opportunities and capabilities of information technology
“Molecular Microbiology: Diagnostic Principles and Practice” is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians.
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The New Microbiology
From Microbiomes to CRISPR
by Pascale Cossart
Part 52 of the ASM Books series
Microbiology has undergone radical changes over the past few decades, ushering in an exciting new era in science. In The New Microbiology, Pascale Cossart tells a splendid story about the revolution in microbiology, especially in bacteriology. This story has wide-ranging implications for human health and medicine, agriculture, environmental science, and our understanding of evolution. The revolution results from the powerful tools of molecular and cellular biology, genomics, and bioinformatics, which have yielded amazing discoveries, from entire genome sequences to video of bacteria invading host cells. This book is for both scientists and especially nonscientists who would like to learn more about the extraordinary world of bacteria.
Dr. Cossart's overview of the field of microbiology research, from infectious disease history to the ongoing scientific revolution resulting from CRISPR technologies, is presented in four parts.
• New concepts in microbiology introduces the world of bacteria and some recent discoveries about how they live, such as the role of regulatory RNAs including riboswitches, the CRISPR defense system, and resistance to antibiotics.
• Sociomicrobiology: the social lives of bacteria helps us see the new paradigm by which scientists view bacteria as highly social creatures that communicate in many ways, for example in the assemblies that reside in our intestine or in the environment.
• The biology of infections reviews some of history's worst epidemics and describes current and emerging infectious diseases, the organisms that cause them, and how they produce an infection.
• Bacteria as tools introduces us to molecules derived from microbes that scientists have harnessed in the service of research and medicine, including the CRISPR/Cas9 genome-editing technology. “The New Microbiology” takes us on a journey through a remarkable revolution in science that is occurring here and now.
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Twelve Diseases That Changed Our World
by Irwin W. Sherman
Part 60 of the ASM Books series
Covers the history of twelve important diseases and addresses public health responses and societal upheavals.
• Chronicles the ways disease outbreaks shaped traditions and institutions of Western civilization.
• Explains the effects, causes, and outcomes from past epidemics.
• Describes a dozen diseases to show how disease control either was achieved or failed.
• Makes clear the interrelationship between diseases and history.
• Presents material in a compelling, clear, and jargon-free prose for a wide audience.
• Provides a picture of the best practices for dealing with disease outbreaks.
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Practical Guide to Diagnostic Parasitology
by Lynne Shore Garcia
Part 141 of the ASM Books series
In the 21st century the field of diagnostic medical parasitology continues to see dramatic changes, including newly recognized pathogens and the changing endemicity and classification of familiar organisms; neglected tropical diseases and the impact of global climate change; and new methodologies and risk management issues. This classic clinical laboratory parasitology reference, now in its third edition, has been extensively revised and updated in a new full-color format. Still organized to provide maximum help to the user, particularly from the bench perspective, every section has been expanded with new images and discussion.
Specimen collection, preservation, and testing options are thoroughly discussed, from the routine ova and parasite examination to blood films, fecal immunoassays, and the newer molecular test panels. Specific test procedures, laboratory methods and reagents, and algorithms are provided. The ever-helpful "FAQ" section of commonly asked questions now offers expanded information on stool specimen fixatives and testing, thorough coverage of new techniques, and advice on reporting and commenting on results.
The heart of the Guide, covering identification of individual pathogens, has been expanded with more discussion and comparison of organisms and dozens of new color images. An entirely new section has been added that uses extensive figures and new tables to illustrate common problems with differentiating organisms from one another and from possible microscopic artifacts. The final section has been reorganized to include identification keys and dozens of tables summarizing organism characteristics to assist the bench microbiologist with routine diagnostic testing methods.
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Bacteria and Intracellularity
by Pascale Cossart
Part of the ASM Books series
“Bacteria and Intracellularity” clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria.
This book offers a wide-ranging look at the latest studies, including:
• foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiota
• infections of the urogenital tract, endothelial barriers, and the nervous system
• major advances in work with Mycobacterium tuberculosis and M. leprae
• subcellular microbiology, including metabolism of infected cells, nuclear biology, and microRNAs
• endosymbionts, in particular the latest work with Wolbachia and its effect on insect transmission of viral pathogens
• research into cell autonomous defense pathways that has led to major insights into immunology and innate immunity
• the latest developments in technology, for the next steps in the study of intracellularity
All facets of cellular physiology, within the entire scope of cells and host tissues, can be targeted by pathogens. This book offers to researchers, students, and laboratorians a valuable overview of the state of current research into the cellular microbiology of host-pathogen interactions.
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Color Atlas of Medical Bacteriology
by Luis M. De La Maza
Part of the ASM Books series
This unique visual reference presents more than 750 brilliant, four-color images of bacterial isolates commonly encountered in diagnostic microbiology and the methods used to identify them, including microscopic and phenotypic characteristics, colony morphology, and biochemical properties.
• Chapters cover the most important bacterial pathogens and related organisms, including updated taxonomy, epidemiology, pathogenicity, laboratory and antibiotic susceptibility testing, and molecular biology methodology
• Tables summarize and compare key biochemical reactions and other significant characteristics
• New to this edition is a separate chapter covering the latest developments in total laboratory automation
• The comprehensive chapter on stains, media, and reagents is now augmented with histopathology images
• A new Fast Facts chapter presents tables that summarize and illustrate the most significant details for some of the more commonly encountered organisms
For the first time, this easy-to-use atlas is available digitally for enhanced searching. “Color Atlas of Medical Bacteriology” remains the most valuable illustrative supplement for lectures and laboratory presentations, as well as for laboratorians, clinicians, students, and anyone interested in diagnostic medical bacteriology.
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Thinking About Science
Good Science, Bad Science, and How to Make It Better
by Ferric C. Fang
Part of the ASM Books series
Thinking about Science: Good Science, Bad Science, and How to Make It Better
A riveting exploration of the world of science, diving headfirst into its triumphs and tribulations.
Penned by seasoned microbiologists Ferric C. Fang and Arturo Casadevall, this book offers a comprehensive analysis of the scientific enterprise through various lenses, including historical, philosophical, and personal.
From their unique vantage points as researchers, clinicians, and educators, Fang and Casadevall dissect the intricate mechanisms of science, shedding light on its strengths and weaknesses. Through engaging historical anecdotes, personal narratives, and insightful academic studies, they present a candid evaluation of science�s performance, including a thought-provoking examination of its role during the COVID-19 pandemic.
A must-read for anyone curious about the present predicaments and future potential of science, Thinking about Science: Good Science, Bad Science, and How to Make It Better is more than just a book; it�s a roadmap to understanding and improving the scientific endeavor for the benefit of society at large.
�The authors have given us a thoughtful description of science and the joy of discovery, an unflinching diagnosis of where improvements are needed, and recommendations for remedies well worth considering. Scientists, science and society would benefit if this book were read by both future and established scientists, as well as the administrators, policymakers, and regulators who are in a position to help us do better.�
�Michael Kalichman, UC San Diego
�With a deep understanding of the profound impact of science on society, the authors provide thought-provoking perspectives on changes in the scientific enterprise that will support sustainable, equitable practices, and engender public trust. An engaging read for everyone with an interest in science or science policy. �
�Stanley Maloy, San Diego State University
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101 Topics for Clinical Microbiology Laboratory Leaders
Accreditation, Verification, Quality Systems, and More
by Rebekah M. Martin
Part of the ASM Books series
Successfully manage your laboratory accreditation and compliance audits with this easily accessible how-to resource for clinical laboratories
101 Topics for Clinical Microbiology Laboratory Leaders: Accreditation, Verification, Quality Systems, and More by Rebekah M. Martin is your roadmap to achieving and maintaining excellence in clinical microbiology laboratory administration. This quick reference guide is designed to help laboratory professionals efficiently navigate the key aspects of accreditation, regulatory compliance, and quality management. This practical resource is perfect for both new and experienced laboratory leaders who need accessible, actionable information.
Inside, you'll find:
• Regulatory Overview: Information on the Clinical Laboratory Improvement Amendments, test complexity categories, and the roles of key agencies like the Centers for Medicare & Medicaid Services, the Centers for Disease Control and Prevention, and the Food & Drug Administration in overseeing clinical laboratories.
• Accreditation Basics: Guidance on how to obtain and maintain laboratory accreditation, including what to expect during inspections and how to respond to deficiencies.
• Test Verification & Validation: Essential tips on conducting verification and validation studies to ensure your laboratory's test systems are accurate, reliable, and compliant with regulatory standards.
• Quality Management Essentials: Practical strategies for implementing and maintaining a quality management system, including process control, document management, and continuous improvement techniques that keep your lab running smoothly.
Presented in a user-friendly question-and-answer format, 101 Topics for Clinical Microbiology Laboratory Leaders is your go-to resource for quick, reliable guidance on leading a compliant and high-performing clinical microbiology laboratory.
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Clinical Laboratory Management
by Various Authors
Part of the ASM Books series
Clinical Laboratory Management
Apply the principles of management in a clinical setting with this vital guide
Clinical Laboratory Management, Third Edition, edited by an esteemed team of professionals under the guidance of editor-in-chief Lynne S. Garcia, is a comprehensive and essential reference for managing the complexities of the modern clinical laboratory. This newly updated and reorganized edition addresses the fast-changing landscape of laboratory management, presenting both foundational insights and innovative strategies.
Topics covered include:
• an introduction to the basics of clinical laboratory management, the regulatory landscape, and evolving practices in the modern healthcare environment
• the essence of managerial leadership, with insights into employee needs and motivation, effective communication, and personnel management, including the lack of qualified position applicants, burnout, and more
• financial management, budgeting, and strategic planning, including outreach
• up-to-date resources for laboratory coding, reimbursement, and compliance, reflecting current requirements, standards, and challenges
• benchmarking methods to define and measure success
• the importance of test utilization and clinical relevance
• future trends in pathology and laboratory science, including developments in test systems, human resources and workforce development, and future directions in laboratory instrumentation and information technology
• an entirely new section devoted to pandemic planning, collaboration, and response, lessons learned from COVID-19, and a look towards the future of laboratory preparedness
This indispensable edition of Clinical Laboratory Management not only meets the needs of today's clinical laboratories but anticipates the future, making it a must-have resource for laboratory professionals, managers, and students. Get your copy today, and equip yourself with the tools, strategies, and insights to excel in the complex and ever-changing world of the clinical laboratory.
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Emerging Infections 10
by Various Authors
Part of the ASM Books series
Essential resource for the fight against emerging infectious diseases
Incidences such as the 2014 Ebola epidemic in West Africa and the 2015 appearance of Zika in Brazil provide dramatic evidence of the continued ability of microbes to emerge, spread, adapt, and threaten global health. The challenge facing infectious disease specialists and public health professionals is to improve and find new diagnostic, therapeutic, and prevention strategies.
The editors of the 10th installment of the Emerging Infections series have compiled the perspectives of leading infectious disease experts into 22 chapters that provide important updates on a broad range of emerging and reemerging bacterial, viral, parasitic, and fungal infectious diseases in the United States and globally. In addition to focusing on MERS, Ebola virus disease, chikungunya, and Zika virus disease, Emerging Infections 10 explores the global threat of antimicrobial resistance in reviews on carbapenem-resistant Enterobacteriaceae, multiply-resistant gonococcal infections, non-typhoidal Salmonella infections, and artemisinin-resistant Plasmodium falciparum malaria. Topics include both recently-and long-recognized diseases that pose challenges for the clinical, laboratory, research, public health, and animal health communities.
Emerging Infections 10 presents new and emerging strategies to prevent, control, and eradicate infectious diseases and guides readers to the primary literature where they can explore individual topics in greater depth. This book is a valuable reference for professionals in microbiology, epidemiology, public health, and clinical and veterinary medicine.
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Antimicrobial Resistance in Bacteria From Livestock and Companion Animals
by Various Authors
Part of the ASM Books series
The global spread of antimicrobial-resistant pathogenic bacteria is a continuing challenge to the health care of humans and domesticated animals. With no new agents on the horizon, it is imperative to use antimicrobial agents wisely to preserve their future efficacy.
Led by Editors Stefan Schwarz, Lina Maria Cavaco, and Jianzhong Shen with Frank Møller Aarestrup, an international team of experts in antimicrobial resistance of livestock and companion animals has created this valuable reference for veterinary students and practitioners as well as researchers and decision makers interested in understanding and preventing antimicrobial resistance.
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Regulating with RNA in Bacteria and Archaea
by Various Authors
Part of the ASM Books series
Revealing the many roles of RNA in regulating gene expression
For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes.
Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have specific functions, including small RNAs (sRNA), RNA thermometers, and riboswitches to regulate core metabolic pathways, bacterial pathogenesis, iron homeostasis, quorum sensing, and biofilm formation.
All of these functions, and more, are presented in Regulating with RNA in Bacteria and Archaea, written by RNA biologists from around the globe. Divided into eight sections-RNases and Helicases, Cis-Acting RNAs, Cis Encoded Base Pairing RNAs, Trans-Encoded Base Pairing RNAs, Protein Titration and Scaffolding, General Considerations, Emerging Topics, and Resources-this book serves as an excellent resource for established RNA biologists and for the many scientists who are studying regulated cellular systems.
It is no longer a fair assumption that gene expression regulation is the provenance of proteins only or that control is exerted primarily at the level of transcription. This book makes clear that regulatory RNAs are key partners along with proteins in controlling the complex interactions and pathways found within prokaryotes.
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One Health
People, Animals, and the Environment
by Various Authors
Part of the ASM Books series
Emerging infectious diseases are often due to environmental disruption, which exposes microbes to a different niche that selects for new virulence traits and facilitates transmission between animals and humans. Thus, health of humans also depends upon health of animals and the environment—a concept called One Health. This book presents core concepts, compelling evidence, successful applications, and remaining challenges of One Health approaches to thwarting the threat of emerging infectious disease.
Written by scientists working in the field, this book will provide a series of "stories" about how disruption of the environment and transmission from animal hosts is responsible for emerging human and animal diseases.
• Explains the concept of One Health and the history of the One Health paradigm shift.
• Traces the emergence of devastating new diseases in both animals and humans.
• Presents case histories of notable, new zoonoses, including West Nile virus, hantavirus, Lyme disease, SARS, and salmonella.
• Links several epidemic zoonoses with the environmental factors that promote them.
• Offers insight into the mechanisms of microbial evolution toward pathogenicity.
• Discusses the many causes behind the emergence of antibiotic resistance.
• Presents new technologies and approaches for public health disease surveillance.
• Offers political and bureaucratic strategies for promoting the global acceptance of One Health.
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Manual of Clinical Microbiology, 4 Volume Set
by Various Authors
Part of the ASM Books series
Revised by a collaborative, international, interdisciplinary team of editors and authors, this edition of the Manual of Clinical Microbiology includes the latest applications of genomics and proteomics and is filled with current findings regarding infectious agents, leading-edge diagnostic methods, laboratory practices, and safety guidelines. This edition also features four new chapters: Diagnostic Stewardship in Clinical Microbiology; Salmonella; Escherichia and Shigella; and Morganellaceae, Erwiniaceae, Hafniaceae, and Selected Enterobacterales. This seminal reference of microbiology continues to set the standard for state-of-the-science laboratory practice as the most authoritative reference in the field of microbiology.
If you are looking for online access to the latest from this reference or site access for your lab, please visit www.wiley.com/learn/clinmicronow.
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Urinary Tract Infections
Molecular Pathogenesis and Clinical Management
by Matthew A. Mulvey
Part of the ASM Books series
A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow.
“Urinary Tract Infections: Molecular Pathogenesis and Clinical Management” brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas:
• clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis
• the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae
• the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeutics
This essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic.
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Manual of Molecular Microbiology
Fundamentals And Applications
by Various Authors
Part of the ASM Books series
Your essential guide to design, operation, management, and health care integration of the modern molecular microbiology laboratory
This comprehensive resource offers definitive guidance on the operational and interpretive aspects of clinical molecular microbiology. Tailored for medical laboratory professionals, it provides practical "how-to" guidance for establishing, maintaining, and advancing molecular microbiology testing services and details the unique expertise required to support infectious disease diagnostics.
The Manual offers a clear and practical roadmap for topics ranging from selecting appropriate technologies, instruments, and analytic pipelines to navigating complex interpretive challenges and positioning diagnostic testing services for future clinical and population health needs.
Beginning with foundational technologies and their clinical applications, this book offers accessible overviews of each method's potential, implications, and emerging roles. Subsequent sections dive meticulously into details of laboratory setup, design, and operations, empowering readers with hands-on insights for routine and advanced testing methods, including advanced sequencing technologies. It also tackles the nuanced challenges of interpreting and reporting results from cutting-edge diagnostics, including those focused on antimicrobial resistance and metagenomics.
The final section explores the broader impact of molecular microbiology on value-based care, with discussions on clinical management, laboratory stewardship, and the future of molecular diagnostics in public health.
Comprehensive and forward-looking, the Manual of Molecular Microbiology equips readers with both foundational knowledge and practical expertise, making it an indispensable reference for today's clinical laboratory professionals.
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CRISPR
Biology and Applications
by Various Authors
Part of the ASM Books series
CRISPR-Cas systems have revolutionized the science of gene editing and their possible applications continue to expand, from basic research to potentially groundbreaking medical and commercial uses.
Led by a distinguished team of editors, CRISPR: Biology and Applications explores the subject matter needed to delve into this fascinating area. Topics covered include:
• Classification and molecular mechanisms of CRISPR-Cas systems
• CRISPR-Cas evolution, regulation, expression, and function
• Uses for gene editing and modulation of gene expression
• CRISPR-based antimicrobials and phage resistance for medical and industrial purposes
Written by internationally renowned authors, “CRISPR: Biology and Applications” serves as both an introductory guide for those new to the field and an authoritative reference for seasoned researchers whose work touches this evolving and headline-making science.
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In the Company of Microbes
Ten Years of Small Things Considered
by Moselio Schaechter
Part of the ASM Books series
A look at the amazing, groovy world of microbes
With more than 1,000 posts and 2 million views, the esteemed blog “Small Things Considered“ has been sparking the imagination of microbiologists for an entire decade. Throughout the years, Elio Schaechter and his team of dedicated bloggers have shared exciting, unexpected, and unusual stories from the microbial world.
“In the Company of Microbes” is a carefully selected treasure chest of wise, amusing, and even profound statements about the ubiquity and relevance of the microbial world. Schaechter, past ASM Presidents, and distinguished microbiologists from around the globe reflect on personal, sometimes historic interactions with microbes and unexpected discoveries, each essay conveying the excitement and sense of surprise that microbiology holds for them. This is the reason that Small Things Considered is a scientific and social media phenomenon that has impacted scientists at every stage of their careers and shared the magical of microbes with world.
Join Schaechter in discovering a never-ending pageant of astounding variations on the theme of microbial life. Enjoy!
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Microbial Transmission
by Various Authors
Part of the ASM Books series
Microbial transmission, the processes by which microbes transit to new environments, is a significant and broad-reaching concept with applications throughout the biological sciences. This collection of reviews, edited by an international team of experts studying and working across a range of disciplines, explores transmission not just as an idea in disease but as a fundamental biological process that acts in all domains of nature and exerts its force on disparate size scales, from the micro to the macro, and across units of time as divergent as a single bacterial replication cycle and the entire course of evolution.
In five sections, this overview
• Defines the concept of transmission and covers basic processes of transmission, including causality, control strategies, fitness costs, virulence, and selection
• Presents numerous combinations of transmission scenarios across the bacterial, animal, and human interface
• Examines transmission as the defining characteristic of infectious disease
• Presents methods for experimentally verifying and quantifying transmission episodes
• Concludes with important theoretical and modeling approaches
Anyone studying or working in microbial colonization, evolution, pathogenicity, antimicrobial resistance, or public health will benefit from a deeper understanding of Microbial Transmission.
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Paleomicrobiology of Humans
by Various Authors
Part of the ASM Books series
Only recently was it determined that two of the world's most devastating plagues, the plague of Justinian and the medieval Black Death, were caused by distinct strains of the same pathogen. Use of paleomicrobiological techniques led to this discovery. This work is just one example of the historical mysteries that this emerging field has helped to clarify. Others, such as when tuberculosis began to afflict humans, the role of lice in plague pandemics, and the history of smallpox, are explored and further illuminated in Paleomicrobiology of Humans.
Led by editors Michel Drancourt and Didier Raoult, the book's expert contributors address larger issues using paleomicrobiology. These include the recognition of human remains associated with epidemic outbreaks, identification of the graves of disasters, and the discovery of demographic structures that reveal the presence of an epidemic moment. In addition, the book reviews the technical approaches and controversies associated with recovering and sequencing very old DNA and surveys modern human diseases that have ancient roots.
Essentially, paleomicrobiologists aim to identify past epidemics at the crossroads of different specialties, including anthropology, medicine, molecular biology, and microbiology. Thus, this book is of great interest not only to microbiologists but to medical historians and anthropologists as well.
Paleomicrobiology of Humans is the first comprehensive book to examine so many aspects of this new, multidisciplinary, scientific field.
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Prepare and Protect
Safer Behaviors in Laboratories and Clinical Containment Settings
by Sean G. Kaufman
Part of the ASM Books series
Biological safety is a critical requirement when working with or around infectious disease agents. To prevent exposures and keep staff and patients safe, laboratories and health care facilities rely on personal protective equipment, standard operating procedures (SOPs), and engineering controls. In an instant, however, a single inappropriate human behavior can negate any of these safeguards.
This reference provides an important call to action for anyone who relies on safety plans to consider carefully the humans who must follow those plans. Written by an expert in behavioral biosafety training, Prepare and Protect offers a common-sense program for addressing and reducing the risk factors of human behavior. Learn how to
• Examine the safety culture of your organization and its approach to risk
• Motivate the compliance, adherence to rules, and community thinking that keep everyone safe
• Evaluate, validate, and verify SOPs and staff competence
• Create safety plans and safety training programs that connect outcomes to behaviors
• Provide leadership that translates the containment philosophy from words to actions
The critical message of this book is illustrated and enriched by personal accounts from infectious disease pioneers, from lab safety directors and trainers to the researchers and health care workers directly affected by infectious hazards.
If your work involves pathogenic microbes-whether treating patients in a hospital emergency department or conducting research in a biosafety level 2 or higher laboratory-or overseeing those who do these jobs, this resource will teach you how to develop a culture of biosafety through behavior.
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Antisepsis, Disinfection, and Sterilization
Types, Action, and Resistance
by Gerald E. McDonnell
Part of the ASM Books series
“Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance”, by Gerald E. McDonnell, is a detailed and accessible presentation of the current methods of microbial control. Each major category, such as physical disinfection methods, is given a chapter, in which theory, spectrum of activity, advantages, disadvantages, and modes of action of the methods are thoroughly and clearly presented. Sufficient background on the life cycles and general anatomy of microorganisms is provided so that the reader who is new to microbiology will better appreciate how physical and chemical biocides work their magic on microbes. Other topics in the book include:
• Evaluating the efficacy of chemical antiseptics and disinfectants, and of physical methods of microbial control and sterilization.
• Understanding how to choose the proper biocidal product and process for specific applications.
• Classic physical and chemical disinfection methods, such as heat, cold, non-ionizing radiation, acids, oxidizing agents, and metals.
• Newer chemical disinfectants, including, isothiazolones, micro-and nano-particles, and bacteriophages as control agents.
• Antisepsis of skin and wounds and the biocides that can be used as antiseptics.
• Classic methods of physical sterilization, such as, moist heat and dry heat sterilization, ionizing radiation, and filtration, along with newer methods, including, the use of plasma or pulsed light.
• Chemical sterilization methods that use ethylene oxide, formaldehyde, or a variety of other oxidizing agents.
• A detailed look at the modes of action of biocides in controlling microbial growth and disrupting microbial physiology.
• Mechanisms that microorganisms use to resist the effects of biocides.
The second edition of “Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance” is well suited as a textbook and is outstanding as a reference book for facilities managers and application engineers in manufacturing plants, hospitals, and food production facilities. It is also essential for public health officials, healthcare professionals, and infection control practitioners.
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Forgotten People, Forgotten Diseases
The Neglected Tropical Diseases and Their Impact on Global Health and Development
by Peter J. Hotez
Part of the ASM Books series
The neglected tropical diseases (NTDs) are among the most common infections of the world's poorest people and have profound ramifications on affected populations, including physical, mental, social, and economic. This third edition of Forgotten People, Forgotten Diseases coincides with the third decade of the NTDs movement, which has given access to essential NTD preventative treatments and medications to more than 1 billion people.
Professor Peter Hotez, MD, PhD, one of the founders of the NTD movement, discusses how the NTD space evolved and control was implemented against these ancient scourges, through alliances between nongovernmental development organizations and private-public partnerships. Forgotten People, Forgotten Diseases also
• Reports on the health and economic effects of the NTDs, and the challenges of measuring diseases that do not always kill, but adversely affect productivity, child development, pregnancy outcome, and economic development.
• Lays a roadmap for continued control of existing and newly identified NTDs and spotlights potential opportunities for reducing global poverty and "repairing the world."
• Describes a global initiative to provide annual mass drug administration for more than one billion people affected by NTDs.
• Highlights the role of innovation and product development partnerships for new treatments and vaccines.
• Explains how science and vaccine diplomacy ensure that a new generation of biotechnologies reaches the world's poorest people.
“Forgotten People, Forgotten Diseases” remains an essential resource for anyone seeking insight into global advocacy coordination and mobilization of resources to combat NTDs and continues to tell the story of the world's people who live in extreme poverty and what it means for them to live with these devastating diseases.
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Clinical Microbiology Procedures Handbook, Multi-Volume
by Various Authors
Part of the ASM Books series
Gold Standard consensus-based procedures from the experts.
The Clinical Microbiology Procedures Handbook, 5th edition, provides those engaged in microbial analysis of clinical specimens with procedures for the detection, identification, and characterization of microorganisms involved in human infections. This unique and valuable collection of step-by-step descriptions of the numerous testing modalities used in the clinical microbiology laboratory was written and edited by highly knowledgeable laboratorians. The 5th edition features two new sections, one on blood cultures and one on MALDI-TOF MS, and the sections on molecular diagnostics, virology, and serology were extensively revised and updated. Presented over multiple volumes, this handbook enables laboratory staff to perform all analyses, including appropriate quality control recommendations, from the receipt of the specimen through processing, testing, interpretation, presentation of the final report, and subsequent consultation.
If you are looking for online access to the latest from this reference or site access for your lab, please visit www.wiley.com/learn/clinmicronow.
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Diagnostic Microbiology of the Immunocompromised Host
by Various Authors
Part of the ASM Books series
Strategies for providing optimal care to this high-risk patient group.
The immunocompromised patient population is increasing throughout the world. Major advances in transplantation techniques have expanded access to lifesaving therapies and improved outcomes in these high-risk populations. An understanding of the biology of these infections, host conditions, and the limitations of technologies used to detect and quantify such pathogens is critical to optimal care.
This new edition of “Diagnostic Microbiology of the Immunocompromised Host” covers all aspects of state-of-the-art diagnostics for infectious complications in the immunocompromised patient. Editors Randall Hayden, Karen Carroll, Yi-Wei Tang and Donna Wolk, assembled the contributions of a team of preeminent authors to discuss a broad range of topics, including
• relevant aspects of host biology, antineoplastic, and transplantation techniques and the basis of immunosuppressive conditions ranging from diabetes to age-related immunosuppression
• approaches, interpretations, and limitations of laboratory diagnosis of infections by a wide range of specific etiologic agents
• laboratory diagnosis of infections of specific organ systems, such as respiratory tract infections, gastrointestinal tract infections, and central nervous system infections
• special topics such as prosthetic devices and catheters, healthcare acquired infections, and morphologic considerations (anatomic pathology)
• future diagnostic technologies and their potential impact on the field
“Diagnostic Microbiology of the Immunocompromised Host” is a resource for laboratory medicine specialists, pathologists, technologists, students, and clinical care professionals who are involved or interested in the care of the immunocompromised host.
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The Bacterial Spore
From Molecules to Systems
by Various Authors
Part of the ASM Books series
The study of bacterial spores spans biosecurity to ecology
The first articles describing the sporulation process were published by Robert Koch and Ferdinand Cohn in the late 19th century. Although most of the work accomplished in the past 50 years has focused on the model organism Bacillus subtilis, more recent work significantly expanded the scope of sporulation research to integrate medically relevant spore pathogens, such as B. anthracis and Clostridium difficile, as well as investigations of the ecology of spore-forming species. This new direction is supported by an explosion of novel techniques that can also be applied to nonmodel organisms, such as next-generation sequencing, metagenomics, and transcriptomics.
“The Bacterial Spore” provides a comprehensive series of reviews of the major topics in spore biology that represent intensive, cutting-edge spore research. Editors Adam Driks and Patrick Eichenberger assembled chapters written by a team of diverse and multidisciplinary experts in biodefense and microbial forensics to produce an overview of topics of spore research, such as spore molecular biology, bioremediation, systems biology, issues in biodefense, and the challenge of food safety that is accessible to any reader, regardless of expertise. The Bacterial Spore also encompasses the diversity of spore research, which will appeal to those seeking to broaden their knowledge.
“The Bacterial Spore” is a reference for a wide range of readers, including geneticists, cell biologists, physiologists, structural and evolutionary biologists, applied scientists, advanced undergraduate and graduate students, and nonresearchers, such as national security professionals.
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Protein Secretion in Bacteria
by Various Authors
Part of the ASM Books series
Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial antagonism and collaboration, host invasion and disruption, and immune evasion. A broad repertoire of mechanisms and macromolecular machines are required to deliver protein substrates across bacterial cell membranes for intended effects. Some machines are common to most, if not all bacteria, whereas others are specific to Gram-negative or Gram-positive species or species with unique cell envelope properties such as members of Actinobacteria and Spirochetes.
“Protein Secretion in Bacteria”, authored and edited by an international team of experts, draws together the many distinct functions and mechanisms involved in protein translocation in one concise tome. This comprehensive book presents updated information on all aspects of bacterial protein secretion encompassing:
• Individual secretory systems—Sec, Tat, and T1SS through the newly discovered T9SS
• Mechanisms, structures, and functions of bacterial secretion systems
• Lipoprotein sorting pathways, outer membrane vesicles, and the sortase system
• Structures and roles of surface organelles, including flagella, pili, and curli
• Emerging technologies and translational implications
“Protein Secretion in Bacteria” serves as both an introductory guide for students and postdocs and a ready reference for seasoned researchers whose work touches on protein export and secretion. This volume synthesizes the diversity of mechanisms of bacterial secretion across the microbial world into a digestible resource to stimulate new research, inspire continued identification and characterization of novel systems, and bring about new ways to manipulate these systems for biotechnological, preventative, and therapeutic applications.
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Myeloid Cells in Health and Disease
A Synthesis
by Various Authors
Part of the ASM Books series
The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells.
In “Myeloid Cells in Health and Disease: A Synthesis”, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including
• the recruitment of myeloid and other immune cells following microbial infection
• the role of myeloid cells in the inflammation process and the repair of damaged tissue
• the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin
• receptors and downstream signaling pathways that are activated following ligand-receptor binding
• roles of myeloid cells during microbial and parasite infections
• contributions of myeloid cells in atherosclerosis
• myeloid-derived suppressor cells in tumor development and cancer
“Myeloid Cells in Health and Disease: A Synthesis” will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.
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A Guide to Specimen Management in Clinical Microbiology
by J. Michael Miller
Part of the ASM Books series
“A Guide to Specimen Management in Clinical Microbiology,” is the classic reference that addresses and meets the needs of everyone in the "total testing process" circle. It provides complete, concise information on the unique needs of the microbiology laboratory regarding specimen management and is the only single source for the specimen management policies required for laboratory results that are accurate, significant, and clinically relevant.
Medical, nursing, and medical technology students, practicing physicians, private practice offices, clinical laboratories, and public health laboratories can turn to this valuable resource to answer their questions on issues such as the correct procedures of specimen selection, collection, transport, and storage in the clinical microbiology laboratory, the rationale associated with the specimen requirements, and proper communication between the lab and its clients.
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Virulence Mechanisms of Bacterial Pathogens
by Various Authors
Part of the ASM Books series
Groundbreaking overview of an enduring topic
Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies.
A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including
• how metabolism shapes the host-pathogen interface
• interactions across species and genera
• mechanisms of the secretion systems
• evasion, survival, and persistence mechanisms
• new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens
Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.