Wiley on Drug Synthesis

The latest entry in the widely read Drug Synthesis series In “Current Drug Synthesis”, accomplished medicinal chemist and researcher Dr. Jie Jack Li and 27 expert coauthors deliver an authoritative and comprehensive discussion of the medicinal chemistry of current drugs, as well as the cutting-edge science involved in their synthesis. The book demystifies the process of modern drug discovery for both industry practitioners and students, while capturing the state-of-the-art techniques used to discover some of the most impactful medicines on the market today. Covering six different disease areas—including infectious disease, cancer, cardiovascular and metabolic disease, the central nervous system, anti-inflammatory disease, and a miscellaneous section—the book explores 18 different drugs before concluding with chapters on computational drug discovery and peptide drugs. Each chapter includes coverage of background material on a relevant drug class or disease indication and key aspects of drug discovery, including structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety. Readers will also find: • Thorough introductions to drugs for infectious diseases, including relebactam, vaborbactam, and baloxavir marboxil • In-depth treatments of cancer-treating drugs, including darolutamide, venetoclax, and osimertinib • Comprehensive explorations of central nervous system drugs, including zuranolone and risdiplam • Extensive discussions of computational drug discovery and peptide drugs Perfect for medicinal, organic, synthetic, and process chemists, Current Drug Synthesis will also earn a place in the libraries of research scientists working in lead optimization and process development, as well as graduate students studying organic chemistry, heterocyclic chemistry, or medicinal chemistry.

“The Art of Drug Synthesis” illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. • Edited by prominent scientists working in drug discovery for Pfizer • Meets the needs of a growing community of researchers in pharmaceutical R&D • Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students • An excellent follow-up to the very successful first book by these editors, “Contemporary Drug Synthesis”, but with all new therapeutic categories and drugs discussed.

Following Contemporary Drug Synthesis and “The Art of Drug Synthesis” (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, “Modern Drug Synthesis” features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors' 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. • Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options • Includes case studies in each chapter • Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines • Explains the advantages of process synthesis versus the synthetic route for drug discovery