• In-depth exploration of neurosurgery mentorship programs, highlighting the critical role mentorship plays in shaping the skills, professional development, and personal growth of mentees in the medical field. • Comprehensive analysis of the development and evolution of neurosurgery in resource-limited settings, with a focus on overcoming challenges such as technological limitations and access to advanced surgical training. • Detailed insights into practical aspect of the mentorship, including surgical simulations, case studies, and hands-on neurosurgical training designed to enhance technical precision and clinical decision-making. • Real examples demonstrating the impact of mentorship programs on career trajectories, skill enhancement, and research productivity, providing a blueprint for developing future mentorship initiatives. • Global perspectives on mentorship in neurosurgery, focusing on international collaboration, and the integration of advanced technologies. • Practical guidelines for implementing mentorship programs in diverse medical settings, with a focus on sustainability, scalability, and adapting to varying levels of resource availability. • Discussion on the importance of fostering teamwork, leadership, and continuous learning in neurosurgery mentorship, ensuring the growth of future medical professionals.