A mysterious weapon invades every screen, and society is instantly thrown into chaos. Kaylee Colton's life is devastated when her brother is infected by the mind weapon and he attempts to kill her, after stabbing their mother. Kaylee flees from her house but finds that she too has been damaged by the mind weapon. She can no longer speak. Her once peaceful neighborhood explodes into total war. Escaping the bloodshed, Kaylee slowly loses her mind as she hides out in an abandoned home. She then learns that a resistance has formed at a local high school, and she accompanies a strange boy to join in the fight. Transfixion tells the struggle between militarism and pacifism, war and peace, as Kaylee Colton becomes the key to unlocking the secret of the hypnosis weapon.
