The Poison Belt

Professor Challenger, the intrepid curmudgeon first introduced in The Lost World, discovers that the Earth is hurtling toward a belt of poisonous gas that may exterminate the human race. He sends an urgent summons to three companions, survivors from his astonishing dinosaur expedition in South America.
And he gives them one alarming command-"Bring oxygen."
Locked together in a sealed room, breathing canisters of oxygen, Professor Challenger, Edward Malone, Lord John Roxton, and Professor Summerlee watch the outside world go mad.
Earth careens into the poison belt. People collapse in their tracks, unmonitored machines run amok … and civilization dies before their eyes.
And their oxygen is running out…
From the creator of Sherlock Holmes, The Poison Belt is the second adventure featuring Sir Arthur Conan Doyle's greatest scientist hero.