Rhinosinusitis With Nasal Polyposis

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a heterogeneous disease that impacts a significant portion of the population. Specific subtypes of the disease include cystic fibrosis, allergic fungal sinusitis, and aspirin-exacerbated respiratory disease. Unfortunately, the majority of patients with CRSwNP do not fall within one of these subtypes, and have variable responses to medical and surgical treatment. There are rapidly evolving theories describing the etiology of CRSwNP that involve alterations in innate immunity, acquired dysfunction of respiratory epithelial cells, and external or environmental factors. This book provides a comprehensive update on the latest theories on the etiology of CRSwNP as well as a review of innovative and effective medical and surgical therapies.