After leaving the R.E.D agency, Joe, Erica, Lulu and Max travel to Alta Palma city, to live in the house they inherited from their mother. Upon arriving things appear as a peaceful town of tranquility but the first catch is the wolf bane. As the story progresses Joe is called to investigate the city, R.E.D is willing to pay him to find lost detectives that have ventured in and disappeared. He meets a whacky but beautiful and smart girl Vanessa Greene who is also there for the same case. Both team up to take on unexpected dangers and try to discover who or what is behind the grizzly murders that begin to take place.
