Lauren Rose moved to Phoenix to begin a new life as she starts a prestigious emergency medicine residency, but she could end up doing life in the Arizona State penitentiary instead. Lauren has always lived in the shadow of her more glamorous sister Liz, the wife of baseball superstar Jake Wakefield. But when Liz is found viciously murdered in her Scottsdale home, the spotlight turns to Lauren as prime suspect in the high-profile investigation. Having lost both parents at an early age, Liz's death leaves Lauren all alone in a new city. Jake's support proves invaluable as she navigates the nightmare her life has become. As Lauren spends time with Jake, they develop a closeness that she finds both comforting and confusing. It's an intimacy forged by their shared grief, their mutual love of baseball, and by the thrill of him pitching a perfect game for the Diamondbacks. Meanwhile, the Scottsdale police repeatedly question Lauren. She objects to a lie detector test as bad science. An arrest warrant is issued. The ensuing trial leads the evening news every night as a rabid public just can't get enough of the sordid proceedings, quickly dubbed "The Trial of the Millennium." Will the outcome be influenced by this media circus?
