Lights! Cameras! Action! Jess is still recovering from her epic showdown with her brother, Aeternum, when she decides to visit her old friend, stunt-woman Lindsay McCabe, on the set of her newest film project. But wait - those assassins aren't in the movie! And they're after Lindsay?! Get ready for your close-up, Jess! Then, when New York Mayor Wilson Fisk starts purging "costumed vigilantes" from his city, you can bet Spider-Woman is on his list! The Kingpin will do anything to bring her down - including going after her loved ones. It's all on the line for Jessica Drew when Fisk unleashes his insidious endgame! But why is Spider-Woman fighting…Spider-Woman?! And what's worse than Spider-Man's Sinister Six? How about Jess' awful assemblage of adversaries: the Anti-Arachnine!
