Replicants are bioengineered humans, once designed by the Tyrell Corporation for use Off-world. After a series of violent rebellions, their manufacture was prohibited, and Tyrell Corp went bankrupt.
Niander Wallace acquired the remains of Tyrell Corp and created a new line of Replicants who obey.
Twenty years ago, in 2019, Ash spared the Replicant Isobel Selwyn, a doppelganger of the wife of industrialist Alexander Selwyn. Together with Alexander's human daughter Cleo, Isobel escaped to the off-world colonies.
Now Isobel has gone missing, rumored to be back on Earth.
Meanwhile, Wallace is hunting for the late Alexander Selwyn's research into Replicant physiology and has sent his creation, LUV, the first Replicant Blade Runner, to search Selwyn's old estate, now occupied by the Replicant called Hythe. Hythe ambushes Luv and defeats her.
