Manny Alvarez mysteriously crashes his car into a fence. He dies en route to the hospital, leaving behind a wife and son. It is up to Dr. G to find out what cut this young man's life short.
A man with diabetes dies after a night out. Meanwhile, an elderly man's decomposing body is found in his son's home. Dr. G realizes that finding the causes of death will be anything but straightforward.
A retired businessman travels from England to Florida to visit his family but dies soon after arriving. Dr. G must now determine what mysteriously killed this healthy man so suddenly.
Amanda Reese breaks out in hives and begins to hyperventilate after returning from a Hurricane Katrina relief effort. Dr. G wonders if an infection caused this young woman's untimely death.
A train passenger behaves oddly en route to Arizona and then disappears. The next day, his bloodied body is found in Texas. Dr. G attempts to piece together this bizarre tragedy.