Could history's two most notorious killers actually be the same man? Jeff Mudgett, great-great-grandson of America's first serial killer and expert con man, H.H. Holmes, and ex-CIA operative Amaryllis Fox team up to investigate the theory that Holmes was Britain's infamous murderer, Jack the Ripper.
The Jack the Ripper letters contain an unexpected link to H.H. Holmes; Scotland Yard's list of credible suspects uncovers a key detail of the manhunt; and eyewitness accounts reveal the face of a killer.
An investigation into the gruesome details of Holmes' infamous Murder Castle leads to the discovery that he may have been killing victims all over Chicago and beyond; while a report surfaces that the Ripper may have killed in the U.S.
Investigating the 1893 World's Fair that turned Chicago into H.H. Holmes' killing ground, Jeff and Amaryllis discover an unexpected connection to the Ripper in the city's police archives.
Holmes goes on the run as his schemes unravel; the investigation picks up his trail and discovers a long lost crime scene that could hold the key to proving Holmes is the Ripper.