Transplant patient and now doctor, Frankie starts her first day in Renal rotation; best friend Lou battles surgery's boys' club; and flatmate Tabb starts as an intern.
Frankie takes on the system to save a patient, and lands in trouble. Lou finds out it's not always wise to have an affair with a boss; and Tabb questions his ability as a doctor.
When a heart transplant patient dies, Frankie fears the surgeons will close ranks to cover up a medical error. Lou realises she and best friend Frankie may be on different sides.
When a patient wants to turn off the device keeping her alive Steele tries to dissuade her. Lou feels betrayed when Frankie takes on a Root Cause Analysis into a patient's death, threatening her job.
When Berger learns Frankie has a fever in the middle of a hospital outbreak, he forces her into a bed for treatment, putting her secret at risk of exposure.
Tanya Kalchuri is forced to tell Frankie she read her medical files - a breach of professional ethics; while Berger works with Eli Nadar to save a patient from deportation.
